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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Method for the solid-phase parallel synthesis of a 6-alkylamino-2-(functionalized-aminomethyl)-2H-1-benzopyran
Jong Yeon Hwang1, Hyung-Sub Choi, Jin-soo Seo
1Medicinal Science Division, Korea Research Institute of Chemical Technology, Yusung-gu, Daejeon 305-600, Korea.
Abstract:
A 2000-member library of benzopyran analogues was prepared by using a solid-phase synthesis protocol. Polymer-bound 6-alkylaminobenzopyrans 7 were synthesized as part of a first generation diversification step by employing reactions of a variety of alkyl halides with the amine 6. Transformations of the resin-bound intermediates 8 formed in this manner by reactions with acid halides, sulfonyl chlorides, and isocyanates leads to introduction of the second level of diversification found in the series of 6-alkylamino-2-(functionalized-aminomethyl)-2-methyl-2H-1-benzopyran analogues 11 and 12.
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