Method for the solid-phase parallel synthesis of a 6-alkylamino-2-(functionalized-aminomethyl)-2H-1-benzopyran

Jong Yeon Hwang1, Hyung-Sub Choi, Jin-soo Seo

  • 1Medicinal Science Division, Korea Research Institute of Chemical Technology, Yusung-gu, Daejeon 305-600, Korea.

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Alkylation is one of the methods used to prepare amines. Direct alkylation of ammonia or a primary amine with an alkyl halide gives polyalkylated amines along with a quaternary ammonium salt through successive SN2 reactions. This process of making the quaternary salt through the direct alkylation method is called exhaustive alkylation.
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Introduction
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Preparation of 1° Amines: Azide Synthesis01:22

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Introduction
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