Related Experiment Video
Updated: Jul 18, 2026
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
Prognostic influence of multiple hepatic metastases from colorectal cancer
H Z Malik1, Z Z R Hamady, R Adair
1HPB and Transplant Unit, St. James's University Hospital, Leeds LS9 7TF, UK.
Aims:
The aim of this study was to report the results of surgery for multiple colorectal liver metastases on patient outcome.
Methods:
This was a review of 484 consecutive patients who underwent liver resection for colorectal liver metastases between 1993 and 2003. The cohort was divided into 2 groups, those with 1-3 metastases and those with "multiple" metastases, namely 4 or more lesions. The later group was subdivided into those with less than 8 ("several") or 8 or more ("numerous") separate lesions.
Main Outcome Measures:
the post-operative hospital stay was calculated and morbidity and mortality were assessed.
Results:
On multivariate analysis the presence of multiple metastases was the only predictor for both poorer overall survival (p=0.007) and disease-free survival (p=0.031). However, when patients with multiple metastases are analysed in detail this survival disadvantage appears to be only present in patients with numerous (8 or more) lesions.
Conclusion:
Although patients with multiple metastases appear to have a poorer outcome, significant number of patients with multiple metastases survive to 5 years or more and should not be denied surgery. Patients with numerous (8 or more) metastases showed a poorer survival disadvantage. These patients need alternative treatment speculatives.
