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Related Experiment Videos

Single-chip microelectronic system to interface with living cells.

F Heer1, S Hafizovic, T Ugniwenko

  • 1Physical Electronics Laboratory, ETH Zürich, ETH Hönggerberg, HPT H 4.2, Wolfgang-Pauli-Strasse 16, CH-8093 Zurich, Switzerland. fheer@phys.ethz.ch <fheer@phys.ethz.ch>

Biosensors & Bioelectronics
|November 14, 2006
PubMed
Summary
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A new CMOS microsystem enables seamless, high-resolution monitoring and stimulation of electrogenic cells. This technology facilitates rapid, real-time study of neural networks and cardiac activity for biological research.

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Electrophysiology

Background:

  • Coordinated electrical activity in neural and cardiac cells is crucial for complex biological functions.
  • Existing techniques for monitoring cellular electrical activity lack sufficient spatiotemporal resolution and seamless integration.
  • Advanced tools are needed to understand neural network development and cardiac function.

Purpose of the Study:

  • To present a monolithic microsystem for bidirectional communication with cultured electrogenic cells.
  • To enable high-resolution, real-time monitoring and stimulation of cellular electrical activity.
  • To provide a versatile platform for studying neural and cardiac cell behavior.

Main Methods:

  • Development of a monolithic microsystem using complementary metal-oxide-semiconductor (CMOS) technology.

Related Experiment Videos

  • Integration of per-electrode circuitry for stimulation and signal treatment.
  • On-chip signal transformation and a digital interface for rapid, real-time interaction (2 ms loop time).
  • Use of the microchip as a direct substrate for neuronal and cardiac cell culturing.

    • Main Results:

    • Demonstration of bidirectional communication between electronics and cultured electrogenic cells.
    • Achieved remarkable signal quality for both spontaneous and stimulated electrical activity recordings.
    • Validated the system's capability with neuronal and cardiac cell cultures.
    • Showcased potential for near real-time feedback loops in cellular studies.

    Conclusions:

    • The presented CMOS microsystem offers a powerful tool for electrogenic cell research.
    • Enables advanced studies in neural network development, plasticity, and pharmacological effects.
    • Facilitates a deeper understanding of coordinated cellular electrical activity in biological systems.