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Updated: Nov 8, 2025
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Whole Cell Recording from an Organotypic Slice Preparation of Neocortex
Published on: June 3, 2011
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Long-Term, High-Spatiotemporal Resolution Recording From Cultured Organotypic Slices with High-Density Microelectrode
1Department of Biosystems Science and Engineering, ETH Zurich, Zurich, Switzerland.
International Solid-State Sensors, Actuators and Microsystems Conference : [Proceedings]. International Conference on Solid-State Sensors, Actuators, and Microsystems
|April 19, 2021
Abstract
None:
A novel system to cultivate and record brain slices directly on high-density microelectrode arrays (HD-MEA) was developed. This system allows to continuously record electrical activity of selected individual neurons at high spatial resolution, while monitoring neuronal network activity at the same time. For the first time, properties of single neurons and the corresponding neuronal network in an organotypic hippocampal slice culture were studied over four consecutive weeks at daily intervals.
Keywords:
High-density microelectrode arrayslong-term experimentorganotypic hippocampal slicesingle neuron tracing
