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High-Density Mapping of Brain Slices using a Large Multi-Functional High-Density CMOS Microelectrode Array System.

Vijay Viswam1, Raziyeh Bounik1, Amir Shadmani1

  • 1Bio Engineering Laboratory, ETH Zurich, Basel, Switzerland.

International Solid-State Sensors, Actuators and Microsystems Conference : [Proceedings]. International Conference on Solid-State Sensors, Actuators, and Microsystems
|September 5, 2017
PubMed
Summary
This summary is machine-generated.

We developed a high-density microelectrode array (HD-MEA) for detailed in-vitro brain slice analysis. This advanced system allows real-time, label-free monitoring of neural activity and slice characteristics.

Keywords:
Action potentialBrain slicesCMOSElectrophysiologyHigh-density microelectrode arraysImpedance measurement

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Area of Science:

  • Neuroscience
  • Bioengineering
  • Materials Science

Background:

  • Current methods for analyzing brain slices in-vitro have limitations in spatial resolution and multiplexed recording capabilities.
  • High-density microelectrode arrays (HD-MEAs) offer a promising approach to overcome these limitations.

Purpose of the Study:

  • To present a novel CMOS-based high-density microelectrode array (HD-MEA) system.
  • To enable high-density, multi-modal in-vitro mapping of brain slices.

Main Methods:

  • Fabrication of a 4.48×2.43 mm2 CMOS-based HD-MEA with 59,760 micro-electrodes at 13.5 µm pitch.
  • Integration of multiple readout modalities including action-potential, local-field-potential, current, impedance, and neurotransmitter detection channels.
  • Implementation of voltage/current stimulation channels.

Main Results:

  • The system supports 2048 action-potential, 32 local-field-potential, 32 current, 32 impedance, 28 neurotransmitter, and 16 stimulation channels.
  • Achieved a high electrode density of 5487 electrodes/mm2.
  • Enabled real-time, label-free monitoring of brain slice position, size, morphology, and electrical activity.

Conclusions:

  • The presented CMOS-based HD-MEA system significantly advances in-vitro brain slice analysis.
  • This technology facilitates comprehensive, high-resolution characterization of neural tissue.
  • The multi-modal capabilities open new avenues for neuroscience research.