High-Density Mapping of Brain Slices using a Large Multi-Functional High-Density CMOS Microelectrode Array System
Vijay Viswam1, Raziyeh Bounik1, Amir Shadmani1
1Bio Engineering Laboratory, ETH Zurich, Basel, Switzerland.
International Solid-State Sensors, Actuators and Microsystems Conference : [Proceedings]. International Conference on Solid-State Sensors, Actuators, and Microsystems
|September 5, 2017
Abstract
None:
We present a CMOS-based high-density microelectrode array (HD-MEA) system that enables high-density mapping of brain slices in-vitro with multiple readout modalities. The 4.48×2.43 mm2 array consists of 59,760 micro-electrodes at 13.5 µm pitch (5487 electrodes/mm2). The overall system features 2048 action-potential, 32 local-field-potential and 32 current recording channels, 32 impedance-measurement and 28 neurotransmitter-detection channels and 16 voltage/current stimulation channels. The system enables real-time and label-free monitoring of position, size, morphology and electrical activity of brain slices.
