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Related Experiment Videos

Quantitative diffusion tensor imaging in amyotrophic lateral sclerosis.

Caroline A Sage1, Ronald R Peeters, Astrid Görner

  • 1Department of Radiology, University Hospitals of the Catholic University of Leuven, Herestraat 49, B-3000 Leuven, Belgium.

Neuroimage
|November 14, 2006
PubMed
Summary
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Amyotrophic lateral sclerosis (ALS) affects the whole brain, not just motor areas. Diffusion tensor imaging (DTI) shows widespread white matter changes and disease progression in ALS patients.

Area of Science:

  • Neuroimaging
  • Neurology
  • Radiology

Background:

  • Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease.
  • Traditionally viewed as a motor neuron disease, emerging evidence suggests broader brain involvement.

Purpose of the Study:

  • To evaluate changes in diffusion tensor imaging (DTI) parameters in the whole brain of ALS patients compared to healthy controls.
  • To assess the correlation between DTI parameters and disease duration/severity.
  • To examine the effect of disease progression on DTI parameters.

Main Methods:

  • Diffusion tensor imaging (DTI) was performed on 28 ALS patients and 26 healthy controls.
  • Fibertracking and voxel-based analysis were used to compare diffusion parameters.
  • Correlation analyses and a follow-up DTI examination were conducted.

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Main Results:

  • Fibertracking identified impairment in the precentral corticospinal tract (CST).
  • Voxel-based analysis revealed widespread diffusion parameter changes in frontal, temporal, and parietal lobes.
  • Reduced fractional anisotropy (FA) correlated with increased disease severity and declined further over time in the CST and whole brain white matter.

Conclusions:

  • ALS is a multisystem degenerative disease with significant extra-motor area involvement.
  • DTI reveals widespread white matter abnormalities in ALS.
  • Abnormalities in extra-motor areas are important in the in vivo physiopathology of ALS.