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A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
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Antigen-receptor signaling to nuclear factor kappa B

Jan Schulze-Luehrmann1, Sankar Ghosh

  • 1Section of Immunobiology and Department of Molecular Biophysics & Biochemistry, Yale University School of Medicine, New Haven, CT 06520, USA.

Immunity
|November 14, 2006
PubMed
Summary

Nuclear factor kappaB (NF-kappaB) is crucial for immune responses. This review details antigen receptor (AgR) signaling pathways that activate the IkappaB kinase (IKK) complex, leading to NF-kappaB transcriptional activity.

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