Related Experiment Video

Updated: Jul 18, 2026

Reconstruct Human Retinoblastoma In Vitro
06:52

Reconstruct Human Retinoblastoma In Vitro

Published on: October 11, 2022

The retinoblastoma protein in osteoblast differentiation and osteosarcoma

Amit Deshpande1, Philip W Hinds

  • 1Molecular Oncology Research Institute, Department of Radiation Oncology, Tufts-New England Medical Center, 750 Washington Street 5609, Boston, MA 02111, USA.

Current Molecular Medicine
|November 15, 2006
PubMed

Insights

Osteogenic sarcoma, the most common bone cancer, frequently involves inactivation of the retinoblastoma gene (RB1). This gene family plays a key role in bone development and tumor formation, particularly in osteoblast-derived tumors.

Area of Science:

  • Orthopedics
  • Oncology
  • Molecular Biology

Background:

  • Osteogenic sarcoma (osteosarcoma) is the most common primary bone tumor, representing about 19% of all bone malignancies.
  • Alterations in the retinoblastoma gene (RB1) are the most frequent molecular changes observed in osteosarcoma genesis.
  • The retinoblastoma gene family is implicated in bone development and tumorigenesis, supported by data from human tumors and experimental models.

Purpose of the Study:

  • To review the role of the retinoblastoma gene family in osteosarcoma.
  • To focus on osteosarcoma arising from the osteoblast lineage.

Main Methods:

  • Review of published data from human osteosarcoma tumors.
  • Analysis of in vivo and in vitro model systems.

Main Results:

  • The retinoblastoma gene (RB1) shows the highest frequency of inactivation in osteosarcoma.
  • Evidence supports the retinoblastoma gene family's role in bone development and tumorigenesis.

Conclusions:

  • The retinoblastoma gene family is critically involved in the development of osteosarcoma.
  • Understanding RB1's role is crucial for studying osteoblast-derived bone tumors.

More Related Videos

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.