Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Urinary carnosine links diet quality with one-carbon and lipid metabolism: insights from an interpretive framework for imidazole metabolites.

European journal of nutrition·2026

Same author

Factors Associated with Owner-Reported Euthanasia in Equids in France.

Journal of equine veterinary science·2021

Same author

Lymphocyte subsets early predict mortality in a large series of hospitalized COVID-19 patients in Spain.

Clinical and experimental immunology·2020

Same author

Identification of levers for improving dead equine traceability: A survey of French equine owners' perception of regulatory procedures following their animal's death.

Preventive veterinary medicine·2019

Same author

Efficiency of three intracellular extraction methods in the determination of metabolites related to tryptophan and tyrosine in winemaking yeast's metabolism by LC-HRMS.

Food chemistry·2019

Same author

Interstitial lung disease in patients with common variable immunodeficiency disorders: several different pathologies?

Clinical and experimental immunology·2019

Search research articles

Related Experiment Video

Updated: Jul 18, 2026

A Detailed Protocol for Characterizing the Murine C1498 Cell Line and its Associated Leukemia Mouse Model

A Detailed Protocol for Characterizing the Murine C1498 Cell Line and its Associated Leukemia Mouse Model

Published on: October 14, 2016

Unusual case presentations associated with the CD45 C77G polymorphism.

E Z Tchilian¹, J Gil, M L Navarro

¹The Edward Jenner Institute for Vaccine Research, Compton, Berkshire, UK.

Clinical and Experimental Immunology

|November 15, 2006

Summary

A common CD45 gene variant (C77G) impacts lymphocyte profiles, potentially contributing to unusual disease presentations in four patients. This finding highlights CD45

More Related Videos

Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation

Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation

Published on: November 3, 2018

Adaptation of Semiautomated Circulating Tumor Cell (CTC) Assays for Clinical and Preclinical Research Applications

Adaptation of Semiautomated Circulating Tumor Cell (CTC) Assays for Clinical and Preclinical Research Applications

Published on: February 28, 2014

Related Experiment Videos

Last Updated: Jul 18, 2026

A Detailed Protocol for Characterizing the Murine C1498 Cell Line and its Associated Leukemia Mouse Model

A Detailed Protocol for Characterizing the Murine C1498 Cell Line and its Associated Leukemia Mouse Model

Published on: October 14, 2016

Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation

Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation

Published on: November 3, 2018

Adaptation of Semiautomated Circulating Tumor Cell (CTC) Assays for Clinical and Preclinical Research Applications

Adaptation of Semiautomated Circulating Tumor Cell (CTC) Assays for Clinical and Preclinical Research Applications

Published on: February 28, 2014

Area of Science:

Immunology
Genetics
Molecular Biology

Background:

CD45 (leukocyte common antigen) is a crucial tyrosine phosphatase in hematopoietic cells.
CD45 regulates immune cell function and is implicated in autoimmune and infectious diseases.
Polymorphisms in CD45 can alter lymphocyte phenotype and function.

Observation:

Four patients presented with diverse diseases and unusual clinical features.
All four patients shared the C77G polymorphism in CD45 exon 4.
This specific polymorphism affects CD45 splicing and lymphocyte CD45RA/CD45R0 expression.

Findings:

The C77G polymorphism in CD45 exon 4 was identified in all four patients.
This genetic variation alters lymphocyte splicing patterns.
The CD45RA/CD45R0 phenotype of lymphocytes was modified by the C77G polymorphism.

Implications:

The C77G CD45 polymorphism may be a contributing factor to the unusual clinical presentations observed.
Understanding CD45 variants is important for diagnosing and managing complex immune-related disorders.
Further research into CD45's role in disease pathogenesis is warranted.