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Neovascularisation: has the angiogenic factor already been found?
1Department of Ophthalmology, Royal Victorian Eye and Ear Hospital, Melbourne, Australia.
Australian and New Zealand Journal of Ophthalmology
|February 1, 1991
Summary
Newly cloned growth factors and inhibitors offer potential for managing ocular neovascularisation. This review explores their role in eye diseases, aiding ophthalmologists in treatment strategies.
Area of Science:
- Ophthalmology
- Molecular Biology
- Biochemistry
Background:
- Soluble growth factors influencing neovascularisation (angiogenesis) are now purified and cloned.
- These molecules play a role in controlling ocular neovascularisation.
- Understanding these factors is crucial for eye research.
Purpose of the Study:
- To review current knowledge on growth factor control of neovascularisation.
- To focus on ocular neovascularisation and molecularly cloned factors.
- To discuss inhibitors of neovascularisation.
Main Methods:
- Literature review of scientific articles.
- Analysis of molecularly cloned growth factors.
- Discussion of neovascularisation inhibitors.
Main Results:
- Several growth factors are identified as key regulators of neovascularisation.
- Molecular cloning provides access to purified, active growth factors.
- Inhibitors of neovascularisation have also been reported.
Conclusions:
- Growth factors and their inhibitors are significant in ocular neovascularisation.
- This knowledge may lead to new treatments for neovascular eye diseases.
- Ophthalmologists can potentially utilize these agents for disease management.