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Updated: Jul 18, 2026

Studying Mitotic Checkpoint by Illustrating Dynamic Kinetochore Protein Behavior and Chromosome Motion in Living Drosophila Syncytial Embryos
Published on: June 14, 2012
ZW10 function in mitotic checkpoint control, dynein targeting and membrane trafficking: is dynein the unifying theme?
Richard B Vallee1, Dileep Varma, Denis L Dujardin
1Deptartment of Pathology and Cell Biology, Columbia University, New York, New York 10032, USA. rv2025@columbia.edu
Abstract:
ZW10 was initially identified as a mitotic checkpoint protein involved in chromosome segregation. It was subsequently implicated in targeting cytoplasmic dynein and dynactin to mitotic kinetochores, though the relationship between these functions remains incompletely understood. Recent studies have revealed that ZW10 performs important functions in nondividing cells as well. These include cytoplasmic dynein targeting to Golgi and other membranes, but also SNARE-mediated ER-Golgi trafficking. Identifying a unifying function for ZW10 in these diverse contexts has been elusive, but likely involves cytoplasmic dynein, as discussed here.
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