Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Growth of Cartilage and Bone Tissue

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Instrumental Avoidance Promotes Safety Learning Across Distributed Neural Circuits.

Biological psychiatry. Cognitive neuroscience and neuroimaging·2026

Same author

Mast Cells Mediate Acute Inflammatory Responses After Glenoid Labral Tears and Can Be Inhibited With Cromolyn in a Rat Model.

The American journal of sports medicine·2024

Same author

Bone healing: Advances in biology and technology.

OTA international : the open access journal of orthopaedic trauma·2023

Same author

Histological Analysis of Regenerative Properties in Human Glenoid Labral Regions.

The American journal of sports medicine·2023

Same author

Distal femur fractures management and evolution in the last century.

International orthopaedics·2023

Same author

Biomolecule-releasing bioadhesive for glenoid labrum repair through induced host progenitor cell responses.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2022

Search research articles

Related Experiment Video

Updated: Jul 18, 2026

Real-time Visualization and Analysis of Chondrocyte Injury Due to Mechanical Loading in Fully Intact Murine Cartilage Explants

Real-time Visualization and Analysis of Chondrocyte Injury Due to Mechanical Loading in Fully Intact Murine Cartilage Explants

Published on: January 7, 2019

Chondrocyte apoptosis and posttraumatic arthrosis.

Joseph Borrelli¹

¹Department of Orthopaedic Surgery, Washington University, School of Medicine, St. Louis, Missouri, USA. borrellij@wustl.edu

Journal of Orthopaedic Trauma

|November 16, 2006

Summary

Chondrocyte apoptosis, programmed cell death in cartilage cells, may contribute to posttraumatic arthrosis after joint injury. Research is ongoing to understand its exact role in osteoarthritis development.

More Related Videos

A Reproducible Cartilage Impact Model to Generate Post-Traumatic Osteoarthritis in the Rabbit

A Reproducible Cartilage Impact Model to Generate Post-Traumatic Osteoarthritis in the Rabbit

Published on: November 21, 2023

Related Experiment Videos

Last Updated: Jul 18, 2026

Real-time Visualization and Analysis of Chondrocyte Injury Due to Mechanical Loading in Fully Intact Murine Cartilage Explants

Real-time Visualization and Analysis of Chondrocyte Injury Due to Mechanical Loading in Fully Intact Murine Cartilage Explants

Published on: January 7, 2019

A Reproducible Cartilage Impact Model to Generate Post-Traumatic Osteoarthritis in the Rabbit

A Reproducible Cartilage Impact Model to Generate Post-Traumatic Osteoarthritis in the Rabbit

Published on: November 21, 2023

Area of Science:

Biomedical Science
Cell Biology
Orthopedics

Background:

Apoptosis, or programmed cell death, is crucial in physiological and pathological processes.
Chondrocytes are the cells responsible for maintaining cartilage tissue.

Purpose of the Study:

To introduce the concept of chondrocyte apoptosis.
To explore its potential contribution to posttraumatic arthrosis following articular injury.

Main Methods:

Review of available methods for assessing chondrocyte apoptosis.
Analysis of findings from in vitro and in vivo studies on cartilage injury.

Main Results:

Various methods exist to detect chondrocyte apoptosis.
Studies show cartilage injury can induce chondrocyte apoptosis.

Conclusions:

The precise role of chondrocyte apoptosis in the development of posttraumatic arthrosis remains undetermined.
Further research is necessary to elucidate the exact contribution of chondrocyte apoptosis to joint degeneration.