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Updated: Jul 18, 2026
09:25
Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
Published on: October 14, 2016
Perinatal factors, growth and development, and osteosarcoma risk
R Troisi1, M N Masters, K Joshipura
1Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-7246, USA. troisir@mail.nih.gov
British Journal of Cancer
|November 16, 2006
Summary
Osteosarcoma risk may be linked to birth size and adolescent growth patterns. Early puberty in males appears protective against developing osteosarcoma, suggesting growth factors influence risk.
Area of Science:
- Pediatric Oncology
- Skeletal Biology
- Epidemiology
Background:
- Osteosarcoma incidence suggests a role for perinatal factors and growth.
- Understanding growth and developmental influences is crucial for osteosarcoma etiology.
Purpose of the Study:
- To investigate the association between perinatal factors, growth, development, and osteosarcoma risk.
- To explore the relationship between birth weight, adolescent growth spurt, puberty timing, and osteosarcoma.
Main Methods:
- Case-control study involving 158 osteosarcoma patients and 141 controls under age 40.
- Data collected via interviews and review of birth and growth records.
- Statistical analysis using age- and sex-adjusted odds ratios (OR) and 95% confidence intervals (CI).
Main Results:
- No association found between current height or height percentiles and osteosarcoma risk.
- Males with osteosarcoma showed an earlier adolescent growth spurt and final height attainment (OR = 7.1).
- Early puberty (facial/pubic hair development) appeared protective (ORs 0.41 and 0.68, respectively).
- High birth weight (≥4000 g) was associated with elevated risk (OR = 3.9), but no dose-response trend observed.
Conclusions:
- Osteosarcoma risk may be influenced by birth size and early adolescent growth.
- Earlier puberty in males might have a protective effect against osteosarcoma.
- Further research is warranted to elucidate the complex interplay of growth factors in osteosarcoma development.
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