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Published on: September 10, 2017
P53 and PCNA immunoexpression in endometrial carcinomas
Cristiana Simionescu1, Claudia Valentina Georgescu, Cl Mărgăritescu
1Department of Pathology, University of Medicine and Pharmacy of Craiova. csimionescu2004@yahoo.com
Summary
This study investigated p53 oncoprotein and PCNA in endometrial carcinomas. While p53 expression varied by differentiation, PCNA indicated higher proliferation in poorly differentiated tumors, though no direct correlation was found.
Area of Science:
- Oncology
- Molecular Biology
- Pathology
Background:
- Endometrial carcinoma is a common gynecologic malignancy.
- The role of p53 oncoprotein and tumor proliferation markers like PCNA in endometrial carcinogenesis requires further elucidation.
Purpose of the Study:
- To analyze p53 oncoprotein involvement in endometrial carcinogenesis.
- To correlate p53 expression with tumor differentiation and proliferative activity (PCNA).
Main Methods:
- Immunohistochemical analysis of p53 oncoprotein in 18 endometrial carcinomas.
- Evaluation of proliferative activity using the PCNA index.
- Categorization of tumors based on differentiation (well-differentiated, poorly differentiated, undifferentiated).
Main Results:
- p53 immunoexpression was positive in 44.4% of cases, with higher intensity in poorly differentiated and undifferentiated tumors.
- All tumors showed PCNA positivity, with higher PCNA indices in poorly differentiated (60%) and undifferentiated (85%) carcinomas compared to well-differentiated (40%).
- PCNA expression correlated with increased proliferative activity, but no significant statistical correlation was found between p53 and PCNA expression.
Conclusions:
- p53 oncoprotein involvement in endometrial carcinogenesis appears linked to tumor differentiation.
- Tumor proliferative activity, assessed by PCNA, is elevated in poorly differentiated endometrial carcinomas.
- The study did not establish a significant statistical correlation between p53 expression and PCNA in endometrial carcinomas.
