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Published on: November 7, 2018

Hepatitis B and C virus co-infections in human immunodeficiency virus positive North Indian patients

Swati Gupta1, Sarman Singh

  • 1Division of Clinical Microbiology, Department of Laboratory Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.

World Journal of Gastroenterology
|November 16, 2006
PubMed

Insights

Hepatitis B and C virus infections are significantly prevalent in human immunodeficiency virus (HIV)-positive patients in New Delhi. Early detection of these hepatitis virus co-infections is crucial for managing HIV care.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Public Health

Background:

  • Human immunodeficiency virus (HIV) infection is a global health concern.
  • Coinfections with hepatitis B virus (HBV) and hepatitis C virus (HCV) are common in HIV-positive individuals.
  • These coinfections can accelerate liver disease progression and complicate treatment.

Purpose of the Study:

  • To determine the prevalence of hepatitis B and C virus infections among HIV-positive patients.
  • To compare infection rates with a control group of healthy donors.
  • To inform clinical management strategies for HIV-infected patients.

Main Methods:

  • Serum samples from 451 HIV-positive patients were tested for HBsAg and HCV antibodies.
  • A control group of healthy bone-marrow and renal donors was included for comparison.
  • Data were collected over a three-year period (January 2003 - December 2005).

Main Results:

  • The prevalence of HBsAg was 5.3% in HIV-positive patients versus 1.4% in controls (P < 0.001).
  • HCV co-infection prevalence was 2.43% in HIV patients, significantly higher than controls (0.7%, P < 0.05).
  • No cases of triple infection (HIV, HBV, and HCV) were observed.

Conclusions:

  • HIV-infected patients exhibit a significantly high prevalence of HBV and HCV infections.
  • Hepatitis virus coinfections in HIV may lead to faster liver disease progression.
  • Early screening for hepatitis virus coinfections in HIV patients is recommended to mitigate risks like hepatotoxicity from antiretroviral therapy.
Abstract

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