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Pasteurella multocida pathogenesis: 125 years after Pasteur.

Marina Harper1, John D Boyce, Ben Adler

  • 1Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Department of Microbiology, Monash University, Melbourne, Australia.

FEMS Microbiology Letters
|November 17, 2006
PubMed
Summary
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Pasteurella multocida causes fowl cholera and other diseases. Research is uncovering how this bacterium invades hosts, evades immunity, and the key virulence factors like capsule and lipopolysaccharide involved in its survival.

Area of Science:

  • Veterinary Microbiology
  • Bacterial Pathogenesis

Background:

  • Pasteurella multocida, identified in 1881, is a significant Gram-negative bacterial pathogen.
  • It causes economically important diseases in diverse hosts, including fowl cholera.

Purpose of the Study:

  • To elucidate the mechanisms of Pasteurella multocida invasion, immune evasion, and systemic disease causation.
  • To identify key bacterial virulence factors contributing to disease development.

Main Methods:

  • Review and synthesis of existing research on Pasteurella multocida virulence.
  • Identification of virulence factors through mutagenesis studies (directed and random).

Main Results:

  • Key virulence factors identified include capsule and lipopolysaccharide (LPS).

Related Experiment Videos

  • Capsule aids in evading phagocytosis and resisting complement.
  • Complete LPS is crucial for bacterial survival within the host.

    • Conclusions:

    • The study highlights known virulence factors (capsule, LPS, PMT, adhesins, iron acquisition proteins) of Pasteurella multocida.
    • Many virulence factors, particularly those for initial attachment, invasion, and persistence, remain to be identified.