Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Formation of the Platelet Plug

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...

Epistaxis

Epistaxis

Epistaxis, or nosebleeds, occurs when small, swollen blood vessels in the nasal mucous membrane rupture. Typically, the anterior septum is the primary site of occurrence.
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...

Structure and Function of Platelets

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Are turkey hens affected by light flicker? Effects on performance and health.

Poultry science·2024

Same author

Do flickering lights impact turkey hen behavior, stress, and fear?

Poultry science·2024

Same author

Investigation of breed differences in plasma adrenocorticotropic hormone concentrations among healthy horses and ponies.

Veterinary journal (London, England : 1997)·2023

Same author

Tunable Three-Body Interactions in Driven Two-Component Bose-Einstein Condensates.

Physical review letters·2022

Same author

Beyond-Mean-Field Effects in Rabi-Coupled Two-Component Bose-Einstein Condensate.

Physical review letters·2021

Same author

The midwife-student mentor relationship: Creating the virtuous circle.

Women and birth : journal of the Australian College of Midwives·2021

Search research articles

Related Experiment Video

Updated: Jul 18, 2026

A Simple Double Centrifugation Tube Method to Obtain Platelet-rich Plasma from Equine Blood

A Simple Double Centrifugation Tube Method to Obtain Platelet-rich Plasma from Equine Blood

Published on: August 15, 2025

Platelets in equine recurrent airway obstruction.

A Hammond¹, S R Bailey, C M Marr

¹Department of Veterinary Clinical Sciences, The Royal Veterinary College, Hawkshead Campus, Hertfordshire AL9 7TA, UK.

Research in Veterinary Science

|November 17, 2006

Summary

Platelets may differ in serotonin uptake in horses with recurrent airway obstruction (RAO). However, antigen exposure did not activate platelets or increase thromboxane production in RAO or normal horses.

More Related Videos

A Porcine Model of Acute Autologous Pulmonary Embolism

A Porcine Model of Acute Autologous Pulmonary Embolism

Published on: September 6, 2024

Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet

Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet

Published on: November 4, 2015

Related Experiment Videos

Last Updated: Jul 18, 2026

A Simple Double Centrifugation Tube Method to Obtain Platelet-rich Plasma from Equine Blood

A Simple Double Centrifugation Tube Method to Obtain Platelet-rich Plasma from Equine Blood

Published on: August 15, 2025

A Porcine Model of Acute Autologous Pulmonary Embolism

A Porcine Model of Acute Autologous Pulmonary Embolism

Published on: September 6, 2024

Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet

Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet

Published on: November 4, 2015

Area of Science:

Veterinary Medicine
Immunology
Pulmonology

Background:

Platelets play a role in allergic airway disease pathogenesis.
Recurrent airway obstruction (RAO) is a hypersensitivity to inhaled antigens in horses.
Understanding platelet function in RAO is crucial for disease management.

Purpose of the Study:

To compare platelet activating factor (PAF)-induced platelet aggregation and thromboxane (Tx) production.
To measure plasma Tx and 5-hydroxytryptamine (5-HT) in ponies with and without RAO.
To assess changes before and after antigen exposure.

Main Methods:

Collected plasma and measured Tx and 5-HT levels.
Induced platelet aggregation with PAF.
Compared measurements between RAO and normal ponies.
Evaluated changes after antigen challenge.

Main Results:

Plasma 5-HT was significantly higher in RAO ponies.
Antigen challenge did not further increase plasma 5-HT.
No significant differences in PAF-induced platelet aggregation or Tx production were observed.
Plasma Tx levels remained unchanged before and after antigen exposure.

Conclusions:

Suggests potential differences in platelet 5-HT uptake in RAO ponies.
Does not provide evidence for platelet activation following antigen exposure in RAO.
Further research is needed to elucidate platelet involvement in RAO pathogenesis.