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Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo
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Immunological aspects of circulating DNA

Philippe Anker1, Maurice Stroun

  • 1OncoXL, 14 chemin de Aulx, 1228 Plan les Ouates/Geneva, Switzerland. panker@worldcom.ch

Annals of the New York Academy of Sciences
|November 17, 2006
PubMed

Nude mice were injected with DNA released by T lymphocytes previously exposed to inactivated herpes symplex type 1 or polio viruses. The serum of these mice was tested for its neutralizing activity. Injected nude mice synthesized antiherpetic or antipolio antibodies, depending on the antigen used to sensitize the T lymphocytes. Mice injected with DNA released by human T cells produced antibodies carrying human allotypes as they could be neutralized by antiallotype sera. However, mice that were injected with DNA released by antigen-stimulated murine T lymphocytes produced antiviral antibodies, which were not neutralized by anti-human allotype sera.

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