Puzzling through fragment-based drug design

Same author

Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design.

Journal of medicinal chemistry·2020

Same author

Labeled Ligand Displacement: Extending NMR-Based Screening of Protein Targets.

ACS medicinal chemistry letters·2014

Same author

Development of a high-content screening assay panel to accelerate mechanism of action studies for oncology research.

Journal of biomolecular screening·2012

Same author

Fragment-based lead discovery: challenges and opportunities.

Journal of computer-aided molecular design·2011

Same author

Identification and characterization of mGlu3 ligands using a high throughput FLIPR assay for detection of agonists, antagonists, and allosteric modulators.

Combinatorial chemistry & high throughput screening·2011

Same author

Navigating the kinome.

Nature chemical biology·2011

Same journal

Cryo-EM sheds light on the mechanism of human telomerase inhibition by BIBR1532.

Nature chemical biology·2026

Same journal

Artificial metalloenzymes in complex biological environments.

Nature chemical biology·2026

Same journal

Allosteric disordering of eIF2B regulates the integrated stress response.

Nature chemical biology·2026

Same journal

A tail of two ligases.

Nature chemical biology·2026

Same journal

Non-canonical cytochrome P450 enzymes expand the diversity of bacterial hemoproteins.

Nature chemical biology·2026

Same journal

Image-guided activation of drugs with electromagnetic radiation.

Nature chemical biology·2026

Related Experiment Videos

Puzzling through fragment-based drug design

Related Concept Videos

Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design.

Labeled Ligand Displacement: Extending NMR-Based Screening of Protein Targets.

Development of a high-content screening assay panel to accelerate mechanism of action studies for oncology research.

Fragment-based lead discovery: challenges and opportunities.

Identification and characterization of mGlu3 ligands using a high throughput FLIPR assay for detection of agonists, antagonists, and allosteric modulators.

Navigating the kinome.

Cryo-EM sheds light on the mechanism of human telomerase inhibition by BIBR1532.

Artificial metalloenzymes in complex biological environments.

Allosteric disordering of eIF2B regulates the integrated stress response.

A tail of two ligases.

Non-canonical cytochrome P450 enzymes expand the diversity of bacterial hemoproteins.

Image-guided activation of drugs with electromagnetic radiation.

Related Experiment Videos

Puzzling through fragment-based drug design

Related Concept Videos

Related Articles

Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design.

Labeled Ligand Displacement: Extending NMR-Based Screening of Protein Targets.

Development of a high-content screening assay panel to accelerate mechanism of action studies for oncology research.

Fragment-based lead discovery: challenges and opportunities.

Identification and characterization of mGlu3 ligands using a high throughput FLIPR assay for detection of agonists, antagonists, and allosteric modulators.

Navigating the kinome.

Cryo-EM sheds light on the mechanism of human telomerase inhibition by BIBR1532.

Artificial metalloenzymes in complex biological environments.

Allosteric disordering of eIF2B regulates the integrated stress response.

A tail of two ligases.

Non-canonical cytochrome P450 enzymes expand the diversity of bacterial hemoproteins.

Image-guided activation of drugs with electromagnetic radiation.