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Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Stroke: Introduction and Types01:29

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...

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Related Experiment Video

Updated: Jul 18, 2026

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
07:56

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats

Published on: April 21, 2017

Diagnostic pitfalls in paediatric ischaemic stroke.

Kees P J Braun1, L Jaap Kappelle, Fenella J Kirkham

  • 1Department of Child Neurology, University Medical Centre Utrecht, the Netherlands. k.braun@umcutrecht.nl

Developmental Medicine and Child Neurology
|November 18, 2006
PubMed
Summary

Diagnosing pediatric ischemic stroke is challenging, often delayed by misinterpreting symptoms. Early recognition and expert evaluation are crucial for timely treatment and better outcomes in children with stroke.

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Last Updated: Jul 18, 2026

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
07:56

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats

Published on: April 21, 2017

Area of Science:

  • Pediatric Neurology
  • Neuroscience
  • Clinical Medicine

Background:

  • Diagnosing ischemic stroke in children is complex.
  • Identifying the cause of pediatric stroke is vital for treatment and prognosis.
  • Childhood stroke risk factors differ significantly from adult patterns.

Purpose of the Study:

  • To investigate diagnostic changes causing delays in pediatric stroke diagnosis.
  • To analyze the impact of diagnostic delays on stroke management in children.
  • To identify factors contributing to misdiagnosis in pediatric ischemic stroke cases.

Main Methods:

  • Retrospective review of 45 pediatric ischemic stroke case histories.
  • Comparison of initial clinical diagnosis with final etiological diagnosis.
  • Evaluation of diagnostic change types, time delays, reasons for change, and management alterations.

Main Results:

  • Twenty-four diagnostic changes were identified, with 19 related to primary diagnosis and 5 to etiological diagnosis.
  • The median delay between initial and final diagnosis was 7 days.
  • Diagnostic changes led to therapeutic alterations in 17 patients.

Conclusions:

  • Pediatric stroke is often not recognized initially due to atypical presentations.
  • Accurate determination of stroke etiology in children requires specialized expertise and time.
  • Recommend evaluation in expert centers with standardized protocols and diligent follow-up for pediatric stroke.