Related Experiment Video

Updated: Feb 24, 2026

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

6.1K

Longitudinal Analysis of Sleep-Disordered Breathing and Cognitive Outcomes in Children Living With Sickle Cell

Shifa Hamdule1, Melanie Koelbel1,2, Johanna C Gavlak1,3

  • 1Developmental Neurosciences Unit and NIHR Biomedical Research Centre, UCL Great Ormond Street Institute of Child Health, London, UK.

Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
|February 23, 2026
PubMed

Insights

Sleep-disordered breathing (SDB) and cognitive function in children with sickle cell anaemia (SCA) were studied. Lower overnight oxygen saturation and central apnoea (CAI) impact cognitive outcomes in children with SCA.

Area of Science:

  • Pediatric Hematology
  • Sleep Medicine
  • Neuropsychology

Background:

  • Sleep-disordered breathing (SDB) and cognitive impairments are prevalent in children with sickle cell anaemia (SCA).
  • Longitudinal data on sleep patterns and cognitive function in this population are limited.

Purpose of the Study:

  • To investigate the longitudinal changes in polysomnographic (PSG) indices in children with SCA.
  • To examine the association between PSG indices and cognitive outcomes in children with SCA.

Main Methods:

  • Utilized data from the Sleep Asthma Cohort (SAC 1-3) with children aged 4-18 years with SCA.
  • Assessed PSG indices including obstructive apnoea hypopnoea index (OAHI), central apnoea index (CAI), oxygen saturation, and total sleep time over two visits.
  • Correlated PSG indices with cognitive assessments at Visit 3.

Main Results:

  • Total sleep time decreased significantly between visits, while overall PSG indices remained stable.
  • Mean overnight oxygen saturation at Visit 1 predicted working memory at Visit 3.
  • Central apnoea index (CAI) at Visit 2 was linked to lower verbal comprehension and executive function scores.

Conclusions:

  • PSG indices showed stability over time, but screening is advised due to sickle cell pathology complexity.
  • Overnight oxygen saturation and central apnoea significantly influence cognitive outcomes in children with SCA.
Abstract

Keywords:
cognitionobstructive sleep apnoeaoxygen saturationpolysomnographysickle cellsleep‐disordered breathing

More Related Videos

Multi-Modal Home Sleep Monitoring in Older Adults07:40

Multi-Modal Home Sleep Monitoring in Older Adults

Published on: January 26, 2019

8.3K
Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

1.6K

Related Concept Videos

Longitudinal Studies01:26

Longitudinal Studies

Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
563
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
468
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
3.2K
Sleep Apnea01:21

Sleep Apnea

Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
622
Longitudinal Research02:20

Longitudinal Research

Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
13.5K