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Updated: Jul 18, 2026

Indirect Immunofluorescence on Frozen Sections of Mouse Mammary Gland

Indirect Immunofluorescence on Frozen Sections of Mouse Mammary Gland

Published on: December 1, 2015

Alveolar and lactogenic differentiation.

Cathrin Brisken¹, Renuga Devi Rajaram

¹National Center of Competence in Research (NCCR) Molecular Oncology, Swiss Institute for Experimental Cancer Research (ISREC), 155 Chemin des Boveresses, CH-1066, Epalinges, Lausanne, Switzerland. Cathrin.Brisken@isrec.ch

Journal of Mammary Gland Biology and Neoplasia

|November 18, 2006

Summary

This review explores signaling pathways controlling mammary gland development and milk secretion. Mouse genetics research reveals key molecular players in alveologenesis and lactogenic differentiation.

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Area of Science:

Developmental Biology
Endocrinology
Molecular Biology

Background:

The mouse mammary gland undergoes significant proliferation and differentiation, regulated by systemic hormones across reproductive stages.
Alveoli, essential for milk secretion, develop from the ductal system during mid/late pregnancy.

Purpose of the Study:

To review the signaling pathways governing mammary gland alveologenesis and lactation.
To highlight the role of hormonal stimuli, local signaling molecules, and intracellular pathways.

Main Methods:

Review of existing literature on mammary gland development.
Analysis of findings from mouse genetics studies.

Main Results:

Identification of an intricate network of signaling pathways connecting hormonal cues to cellular differentiation.
Uncovering key molecular components regulating alveolar development and lactogenesis.

Conclusions:

Mouse genetics provides powerful tools for dissecting mammary gland development.
Understanding these signaling networks is crucial for comprehending lactation and tissue remodeling.