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Pharmacological actions of substance P in the rat vas deferens
H F Miranda1, W I Silva, W W Wolstenholme
1Department of Pharmacology, Faculty of Medicine, Universidad de Chile, Santiago.
Neuropeptides
|April 1, 1991
Abstract:
SP produces two different muscular responses in the isolated vas deferens of the rat. 1) A myotropic, post-synaptic effect that results from stimulation of one subtype of SP receptor, located on the membrane of the smooth muscle (NK-3 receptor). 2) A neurogenic effect at the pre-synaptic level that results from stimulation of another subtype of SP receptor, located on the nerve terminals (NK-1 receptor).