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Relationship between 1,25-dihydroxycholecalciferol levels and functional outcome after hip fracture in elderly
Pedro Carpintero1, Milagros Garcia-Lazaro, Manuel Montero
1Orthopaedics Department, University Hospital Reina Sofia, Avenida Menendez-Pidal S/N, 14004 Cordoba, Spain. pcarpinterob@medynet.com
Abstract:
A prospective study was performed in 109 patients with osteoporotic hip fracture to verify the relationship between 1,25-dihydroxycholecalciferol levels at admission and functional recovery in elderly patients with hip fracture. 47.7% of all the patients had 1,25-dihydroxycholecalciferol levels below the reference values of our laboratory. At 1 year of the fracture only 33 patients (30.3%) had recovered the functional level they had before the fracture. In the bivariate analysis, a statistically significant relationship was found between reduced 1,25-dihydroxycholecalciferol levels and a poorer functional recovery 1 year after the fracture was sustained. A multivariate analysis showed a significant relationship between 1,25-dihydroxycholecalciferol levels and absolute dependence of the patient 1 year after the fracture (P = 0.005; OR 6.97: CI- 1.77-27.41).
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