Related Experiment Videos
[Effect of tranilast (N-5) on cellular immunity--delayed type hypersensitivity]
1Second Department of Internal Medicine, Nagasaki University School of Medicine.
Arerugi = [Allergy]
|March 1, 1991
Summary
Tranilast (N-5), an anti-allergy drug, effectively inhibits T-cell proliferation and lymphokine production. This demonstrates its ability to suppress in vitro cell-mediated immunity and delayed type hypersensitivity reactions.
Area of Science:
- Immunology
- Pharmacology
Context:
- Tranilast (N-5) is a mast-cell stabilizer used for asthma and allergies.
- Previous studies suggest N-5 efficacy in keloids and ulcerative colitis, indicating potential immunomodulatory effects.
Purpose:
- To investigate the immunomodulatory effects of Tranilast (N-5).
- To determine if N-5 inhibits cell-mediated immunity, specifically delayed type hypersensitivity (DTH).
Summary:
- N-5 demonstrated inhibition of BCG-CWS-stimulated lymphocyte proliferation.
- This inhibition was primarily associated with OKT4 positive T cells.
- N-5 suppressed lymphokine production from stimulated lymphocytes, confirming its inhibitory effect on DTH in vitro.
Impact:
- Provides in vitro evidence for N-5's mechanism in suppressing cell-mediated immunity.
- Highlights N-5's potential as an immunomodulator beyond its established anti-allergic applications.
- Suggests N-5 could be explored for conditions involving T-cell mediated inflammatory responses.