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Oral histoplasmosis after radiation therapy for laryngeal squamous cell carcinoma

Khaled Ezzedine1, Isabelle Accoceberry, Denis Malvy

  • 1Travel Clinics and Tropical Disease Unit, Department of Internal Medicine, Infectious Diseases and Tropical Medicine, University Hospital Center. kezzedin@ulb.ac.be

Journal of the American Academy of Dermatology
|November 23, 2006
PubMed

Insights

This case report details a rare instance of Histoplasmosis reactivation in the oropharynx following neck radiation therapy. The study confirms Histoplasma capsulatum as the causative agent in this imported fungal infection.

Area of Science:

  • Infectious Diseases
  • Mycology
  • Oral Medicine

Background:

  • Histoplasmosis is a deep fungal infection, typically asymptomatic, originating in tropical regions.
  • It enters via the respiratory tract and can localize in the oral cavity or metastasize.
  • Oral Histoplasmosis is an important manifestation of this imported systemic mycosis.

Observation:

  • A patient presented with oropharyngeal symptoms after receiving local antitumoral radiation therapy to the neck.
  • The lesion was biopsied and examined using histopathology and staining techniques.

Findings:

  • Histoplasma capsulatum was identified in the oropharyngeal lesion.
  • The findings confirmed H. capsulatum as the causative organism responsible for the patient's symptoms.

Implications:

  • This case highlights the potential for reactivation of latent Histoplasma infections in immunocompromised or treated individuals.
  • It underscores the importance of considering fungal infections in the differential diagnosis of oropharyngeal lesions, especially in patients with a history of radiation therapy.
  • Early diagnosis and appropriate management are crucial for Histoplasmosis reactivation cases.

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