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Neutrophilic dermatoses.

Arturo P Saavedra1, Susanne Christine Kovacs, Samuel L Moschella

  • 1Department of Dermatology, Harvard Medical School, Boston, MA 02115, USA. asoavedra@partners.org

Clinics in Dermatology
|November 23, 2006
PubMed
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Neutrophil infiltration in the skin causes various disorders with distinct presentations. This review covers diagnosis, treatment, associated systemic diseases, and managing challenging cases.

Area of Science:

  • Dermatology
  • Immunology
  • Pathology

Background:

  • Neutrophils are key immune cells that can infiltrate all skin layers.
  • Neutrophil-mediated skin disorders present with diverse clinical and laboratory findings.
  • Understanding these presentations is crucial for accurate diagnosis and effective management.

Purpose of the Study:

  • To provide a comprehensive overview of neutrophil-related skin disorders.
  • To guide clinicians in diagnosis, treatment, and identifying associated systemic conditions.
  • To discuss management strategies for both common and recalcitrant cases.

Main Methods:

  • Review of clinical and laboratory findings associated with neutrophil dermatoses.
  • Discussion of diagnostic approaches for various skin conditions.

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  • Synthesis of treatment options, including systemic therapies and management of difficult cases.

    • Main Results:

    • Neutrophil infiltration leads to a spectrum of skin diseases.
    • Effective diagnosis relies on characteristic clinical and laboratory features.
    • Treatment often requires systemic therapy with consideration of potential side effects.

    Conclusions:

    • Neutrophil dermatoses encompass a range of conditions requiring careful evaluation.
    • Clinicians should consider associated internal diseases in patients with these disorders.
    • Management strategies, including novel therapies, are essential for recalcitrant cases.