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Updated: Jul 18, 2026

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation
Published on: August 23, 2024
Multicentric reticulohistiocytosis
Ani L Tajirian1, Mohsin K Malik, Leslie Robinson-Bostom
1Department of Dermatology, Brown Medical School, Rhode Island Hospital, Providence, RI 02903, USA. ani_tajirian@brown.edu
Abstract:
Multicentric reticulohistiocytosis is a rare granulomatous disease of unknown etiology, characterized by cutaneous nodules and destructive arthritis. Skin lesions can cause significant deformity, and approximately half of affected patients develop a severe disabling arthritis. The disease is often associated with malignancy; however, the paraneoplastic nature of multicentric reticulohistiocytosis is not established. The diagnosis is confirmed by the presence of oncocytic ("ground-glass") histiocytes and multinucleated giant cells on histopathology of the cutaneous nodules and the synovial membrane.
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