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Related Concept Videos

Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
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Related Experiment Video

Updated: Jul 18, 2026

Predicting Treatment Response to Image-Guided Therapies Using Machine Learning: An Example for Trans-Arterial Treatment of Hepatocellular Carcinoma
04:09

Predicting Treatment Response to Image-Guided Therapies Using Machine Learning: An Example for Trans-Arterial Treatment of Hepatocellular Carcinoma

Published on: October 10, 2018

Imaging response assessment in oncology.

S D Curran1, A U Muellner, L H Schwartz

  • 1Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.

Cancer Imaging : the Official Publication of the International Cancer Imaging Society
|November 23, 2006
PubMed
Summary

Advanced imaging rapidly detects tumor response, necessitating updated criteria beyond RECIST for targeted therapies. This evolution accelerates drug development and approval through imaging biomarkers.

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Live Imaging to Quantify Cellular Radiosensitivity in Patient-Derived Tumor Organoids
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Live Imaging to Quantify Cellular Radiosensitivity in Patient-Derived Tumor Organoids

Published on: April 5, 2024

Area of Science:

  • Oncology
  • Radiology
  • Drug Development

Background:

  • Imaging technology advances allow rapid tumor response detection within hours.
  • Development of targeted therapies requires sophisticated response quantification methods.
  • Current Response Evaluation Criteria in Solid Tumors (RECIST) based on size are insufficient.

Purpose of the Study:

  • To highlight the need for updated imaging-based response evaluation criteria.
  • To emphasize the integration of imaging in all drug development phases.
  • To discuss the potential of imaging biomarkers in accelerating drug approval.

Main Methods:

  • Review of current imaging technologies and their application in oncology.
  • Analysis of the limitations of existing response evaluation criteria (RECIST).
  • Discussion of the role of imaging biomarkers and surrogate endpoints.

Main Results:

  • Imaging plays a crucial role from early drug discovery to clinical trials and patient care.
  • Advanced imaging can assess tumor response much faster than traditional methods.
  • Updated, disease-specific criteria are needed to complement or replace RECIST.

Conclusions:

  • Imaging is integral to modern oncology, driving the need for sophisticated response assessment.
  • Imaging biomarkers offer a pathway to significantly expedite drug approval processes.
  • Multidisciplinary collaboration is essential for advancing imaging in cancer research and treatment.