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An Electroporation Method to Transform Rickettsia spp. with a Fluorescent Protein-Expressing Shuttle Vector in Tick Cell Lines
Published on: October 11, 2022
Rickettsiosis in Europe
1Area de Enfermedades Infecciosas, Complejo San Millán-San Pedro-de La Rioja, Hospital de La Rioja, Avd. Viana 1, 26001, Logroño (La Rioja), Spain. jrblanco@riojasalud.es
Abstract:
In Europe, rickettsioses are long-known infectious diseases. Until recently, it was thought that Mediterranean spotted fever due to Rickettsia conorii was the only tick-borne rickettsiosis in Europe. In the last decade new Rickettsia spp. have been implicated in human pathology (R. slovaca, R. sibirica mongolotimonae, R. helvetica). Furthermore, cases of infection due to flea-borne rickettsioses (R. typhi, R. felis) have been described. Finally, although no outbreak of epidemic typhus has been reported yet in central and southern Europe, we should be aware of the possibility of reemergence of this disease in Europe. Other rickettsioses exist that have not yet been implicated in human pathology. We should consider that climate changes and other factors could contribute to the emergence and reemergence of other new diseases.
Insights
Rickettsioses, infectious diseases in Europe, are evolving. New tick-borne and flea-borne Rickettsia species now cause human infections, with potential for epidemic typhus reemergence.
Area of Science:
- Infectious Diseases
- Microbiology
- Public Health
Background:
- Rickettsioses are endemic infectious diseases in Europe.
- Mediterranean spotted fever (Rickettsia conorii) was historically the primary recognized tick-borne rickettsiosis.
- Recent discoveries reveal emerging tick-borne and flea-borne Rickettsia species impacting human health.
Purpose of the Study:
- To review the current landscape of rickettsioses in Europe.
- To highlight newly identified Rickettsia species involved in human infections.
- To underscore the potential for future emergence and reemergence of rickettsial diseases.
Main Methods:
- Literature review of recent epidemiological and etiological data on rickettsioses in Europe.
- Analysis of newly implicated Rickettsia species in human pathology.
- Assessment of factors contributing to disease emergence.
Main Results:
- Several new Rickettsia species (R. slovaca, R. sibirica mongolotimonae, R. helvetica) are now linked to tick-borne human infections.
- Flea-borne rickettsioses caused by R. typhi and R. felis have been documented.
- The potential for epidemic typhus reemergence in central and southern Europe requires vigilance.
Conclusions:
- The spectrum of rickettsioses in Europe is expanding beyond Mediterranean spotted fever.
- Emerging tick-borne and flea-borne Rickettsia infections pose a growing public health concern.
- Climate change and other factors may drive the emergence of novel rickettsial diseases.
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