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An Electroporation Method to Transform Rickettsia spp. with a Fluorescent Protein-Expressing Shuttle Vector in Tick Cell Lines
Published on: October 11, 2022
Rickettsial diseases in Russia
Irina V Tarasevich1, Oleg Y Mediannikov
1Laboratory of Rickettsial Ecology, Gamaleya Institute of Epidemiology and Microbiology, ul. Gamalei, 18, Moscow, Russia. olegusss1@mail.ru
Abstract:
Currently, several rickettsioses are officially being reported in the Russian Federation. These are epidemic typhus and Brill-Zinsser disease, both caused by Rickettsia prowazekii which has a historic prevalence in Russia. Nowadays only single sporadic cases of R. prowazekii infection are reported. The last significant outbreak occurred in 1997 in a mental nursing home, where 29 cases were identified. Registered morbidity of typhus in Russia varies from 0 to 0.01 per thousand for the last decade. Siberian tick typhus, caused by R. sibirica, is registered on a large territory from Pacific coasts to Western Siberia, and its incidence continuously increases, varying between 2.5 and 4.0 thousand officially registered cases per year. Astrakhan spotted fever, caused by R. conorii subsp. caspia has been recognized since 1983. Recently, Far Eastern tick-borne rickettsiosis, caused by R. heilongjiangensis, has been described. Several other pathogenic spotted fever group rickettsiae have been detected and isolated from ticks in Russia; however, they have not yet been linked with clinical cases in these regions.
Insights
Rickettsial infections in Russia include epidemic typhus and increasing Siberian tick typhus. While Rickettsia prowazekii is rare, tick-borne diseases like Siberian tick typhus are rising, with other spotted fever group rickettsiae detected in ticks.
Area of Science:
- * Veterinary Medicine
- * Infectious Diseases
- * Epidemiology
Background:
- * Rickettsioses are a group of bacterial diseases transmitted by ticks and lice.
- * Several rickettsial infections are officially reported in the Russian Federation, with varying incidence rates.
- * Historically, epidemic typhus (Rickettsia prowazekii) was prevalent, but now occurs sporadically.
Purpose of the Study:
- * To review the current status of rickettsioses in the Russian Federation.
- * To highlight the epidemiology of key rickettsial diseases, including Siberian tick typhus and spotted fevers.
- * To note the detection of novel spotted fever group rickettsiae in Russian ticks.
Main Methods:
- * Review of officially reported rickettsioses morbidity data in the Russian Federation.
- * Analysis of incidence trends for Rickettsia prowazekii, Rickettsia sibirica, and other spotted fever group rickettsiae.
- * Inclusion of recently described tick-borne rickettsioses.
Main Results:
- * Epidemic typhus (Rickettsia prowazekii) cases are sporadic, with the last outbreak in 1997.
- * Siberian tick typhus (Rickettsia sibirica) incidence is increasing, with 2.5–4.0 thousand registered cases annually.
- * Astrakhan spotted fever (Rickettsia conorii subsp. caspia) and Far Eastern tick-borne rickettsiosis (Rickettsia heilongjiangensis) are recognized, with other pathogenic rickettsiae found in ticks.
Conclusions:
- * Rickettsial infections remain a public health concern in Russia.
- * Tick-borne rickettsioses, particularly Siberian tick typhus, show a concerning increasing trend.
- * Ongoing surveillance is crucial for detecting and managing emerging rickettsial diseases in the region.
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