Related Experiment Video
Updated: Jul 18, 2026
12:06
Collection of Post-mating Semen from the Female Reproductive Tract and Measurement of Semen Liquefaction in Mice
Published on: November 18, 2017
The semenogelins: proteins with functions beyond reproduction?
M Jonsson1, A Lundwall, J Malm
1Department of Laboratory Medicine, Section for Clinical Chemistry, Lund University, Malmö University Hospital, 205 02, Malmö, Sweden.
Cellular and Molecular Life Sciences : CMLS
|November 23, 2006
Summary
Semenogelins I and II are abundant proteins in human semen. While their reproductive role is unclear due to rapid degradation, recent findings suggest broader physiological functions beyond fertility.
Area of Science:
- Reproductive Biology
- Biochemistry
- Physiology
Background:
- Semenogelins I and II are major coagulum proteins in human semen, secreted by seminal vesicles.
- Their precise physiological functions remain poorly understood, partly due to rapid degradation post-ejaculation.
Purpose of the Study:
- To explore the broader physiological significance of semenogelins beyond their presumed role in reproduction.
- To re-evaluate the functional perspective of semenogelins in human physiology.
Main Methods:
- Literature review and synthesis of recent findings on semenogelins.
- Analysis of biochemical properties and degradation patterns of semenogelins.
Main Results:
- Semenogelins are rapidly degraded in ejaculated semen, complicating functional studies.
- Emerging evidence suggests roles for semenogelins extending beyond reproductive processes.
Conclusions:
- The established view of semenogelins solely in reproduction is likely incomplete.
- Further research is warranted to elucidate the wider physiological implications of semenogelins.
Related Concept Videos
01:22Sperm Structure and Semen Composition
During ejaculation, males release around 2-5 milliliters of semen, which is a complex mixture of mature sperm and various fluids produced by accessory glands. The mature sperm cells measure approximately 60 micrometers in length and consist of a head, neck, midpiece, and tail. The head is flattened and tapered, measuring about 4 to 5 micrometers in length. It contains a nucleus with condensed chromosomes and an acrosome, a cap-like structure filled with enzymes essential for penetrating the...
01:41Spermatogenesis
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male reproductive...
01:22Spermatogenesis
Spermatogenesis is a complex process that involves the development of sperm cells from undifferentiated stem cells in the seminiferous tubules of the testes. The process is essential for the production of mature and functional sperm cells that are capable of fertilizing an egg.
The process of spermatogenesis can be divided into mitosis, meiosis, and spermiogenesis. During mitosis, the spermatogonia or stem cells divide to produce two identical daughter cells, type A and B spermatogonia. Type-A...
The process of spermatogenesis can be divided into mitosis, meiosis, and spermiogenesis. During mitosis, the spermatogonia or stem cells divide to produce two identical daughter cells, type A and B spermatogonia. Type-A...
01:02Role of Septins
Septins are the recently discovered fourth major protein component of the cytoskeleton, along with microfilaments, microtubules, and intermediate filaments. These proteins can associate with other cytoskeletal filaments and carry out varied roles or can be free-floating in the cytoplasm.
Cellular Functions of Septins
Recent studies have revealed the multifaceted roles of septins in various cellular processes such as cytokinesis, ciliogenesis, and neurogenesis. Septins act as scaffolds and...
Cellular Functions of Septins
Recent studies have revealed the multifaceted roles of septins in various cellular processes such as cytokinesis, ciliogenesis, and neurogenesis. Septins act as scaffolds and...
01:31Overview of the Reproductive System
The reproductive system generates offspring, ensuring the survival of the species. In humans, the reproductive system is complex and involves a variety of organs and hormones that work together to ensure successful reproduction.
The gonads, or primary reproductive organs, produce gametes and sex hormones. In males, the testes produce spermatozoa and testosterone, which is responsible for developing secondary male sex characteristics, including a deeper voice, larger muscles, facial and body...
The gonads, or primary reproductive organs, produce gametes and sex hormones. In males, the testes produce spermatozoa and testosterone, which is responsible for developing secondary male sex characteristics, including a deeper voice, larger muscles, facial and body...
01:24Gonadal and Placental Hormones
The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair growth — and...
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair growth — and...