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Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
Published on: December 5, 2015
Bi-directional cell trafficking between mother and fetus in mouse placenta
C Vernochet1, S M Caucheteux, C Kanellopoulos-Langevin
1Laboratory of Immune Regulations and Development, Department of Developmental Biology, J. Monod Institute, UMR 7592 (CNRS and Universities Paris 6 and 7), Tour 43, 2 place Jussieu, 75251 Paris Cedex 05, France.
Placenta
|November 23, 2006
Summary
Maternal and fetal cells traffic between mother and fetus, primarily within the placenta. This bidirectional cell exchange, influenced by genetic differences, may play a role in maternal immune tolerance.
Area of Science:
- Reproductive immunology
- Developmental biology
- Cell biology
Background:
- Cell exchange between mother and fetus during gestation is established.
- The placenta's role in maternal-fetal cell trafficking remains unproven.
Purpose of the Study:
- To visualize maternal-fetal cell exchange at the implantation site.
- To describe bidirectional cell trafficking during gestation.
- To investigate the impact of genetic differences on cell migration.
Main Methods:
- Utilized Enhanced Green Fluorescent Protein (EGFP) transgenic mice.
- Examined syngeneic, allogeneic, and outbred mating types.
- Employed fluorescence microscopy and nested PCR.
Main Results:
- Demonstrated higher maternal-fetal cell exchange frequency in syngeneic and allogeneic gestations compared to outbred.
- Localized maternal cells in the labyrinth and maternal blood sinuses.
- Observed fetal cells invading the decidua and detected in maternal blood and organs.
Conclusions:
- Confirmed bidirectional maternal-fetal cell trafficking within the placenta.
- Suggests a role for cell exchange in establishing maternal tolerance to the fetus.
