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Novel self-assembling nanogels: stability and lyophilisation studies.

S Daoud-Mahammed¹, P Couvreur, R Gref

¹Université Paris-Sud, UMR CNRS 8612, Châtenay-Malabry, France.

International Journal of Pharmaceutics

|November 23, 2006

Summary

New nanogels formed from modified dextran (MD) and beta-cyclodextrin polymer (pbetaCD) showed aggregation in concentrated solutions. Storage at 4°C or freeze-drying improved the stability of these supramolecular nanoassemblies.

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Area of Science:

Polymer science and supramolecular chemistry.
Nanomaterial characterization and stability studies.

Background:

Supramolecular nanoassemblies, specifically nanogels, are formed by associating hydrophobically modified dextran (MD) and beta-cyclodextrin polymer (pbetaCD).
Understanding the stability of these nanogels is crucial for their potential applications.

Purpose of the Study:

To investigate the stability of MD-pbetaCD nanogels using complementary techniques.
To identify factors influencing nanogel destabilization and explore methods for enhancing stability.

Main Methods:

Nanogel size measurements.
Turbidity experiments utilizing a Turbiscan optical analyser.

Main Results:

Nanogels of 120-150nm were consistently produced regardless of polymer concentration.
Concentrated suspensions exhibited increased mean diameter over time due to particle aggregation and/or fusion, not sedimentation.
Stability was enhanced by storage at 4°C and freeze-drying was identified as a viable long-term storage method.

Conclusions:

The primary destabilization mechanism for MD-pbetaCD nanogels is particle aggregation/fusion, particularly in concentrated systems.
Low temperatures and freeze-drying are effective strategies for preserving the integrity of these nanoassemblies.
The findings provide insights into the long-term storage and handling of dextran-based nanogels.