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(Poly-cyanoacrylate) nanomedicines for cancer and beyond: Lessons learned
1Institut Galien Paris-Sud, UMR 8612, CNRS, Univ Paris-Sud, Université Paris-Saclay, Faculté de Pharmacie, 5 rue Jean-Baptiste Clément, F-92296 Châtenay-Malabry, Cedex, France..
Summary
Serendipity drives scientific breakthroughs. Biodegradable nanoparticles, like polyalkylcyanoacrylate and squalenoylation, offer advanced drug delivery for cancer treatment, overcoming key limitations in nanomedicine.
Area of Science:
- Interdisciplinary research
- Nanomedicine
- Drug delivery systems
Background:
- Cell biology discoveries in the 1970s spurred nanotechnologies for intracellular delivery.
- Early nanocapsules faced limitations due to lack of biodegradability.
- Inspiration from surgical glues led to biodegradable nanoparticles.
Purpose of the Study:
- To develop biodegradable nanoparticles for drug delivery.
- To overcome multi-drug resistance in cancer treatment.
- To advance nanomedicine through innovative encapsulation techniques.
Main Methods:
- Design of biodegradable polyalkylcyanoacrylate nanoparticles.
- Utilizing cyanoacrylates as inspiration for material selection.
- Development of drug 'squalenoylation' technology for chemical encapsulation.
Main Results:
- Polyalkylcyanoacrylate nanoparticles demonstrated overcoming multi-drug resistance.
- A nanomedicine based on this technology reached Phase III clinical trials for hepatocarcinoma.
- Squalenoylation significantly increased drug payload and eliminated burst release.
Conclusions:
- Biodegradable nanoparticles represent a significant advance in drug delivery.
- Squalenoylation offers a versatile platform for nanomedicine with broad applications.
- Interdisciplinary approaches and serendipity are crucial for innovation in scientific research.
