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Polymorphism and solvatomorphism 2005.

Harry G Brittain1

  • 1Center for Pharmaceutical Physics, 10 Charles Road, Milford, New Jersey 08848, USA.

Journal of Pharmaceutical Sciences
|November 23, 2006
PubMed
Summary

This review summarizes 2005 research on polymorphism and solvatomorphism, covering crystal structures, preparation, characterization, and phase transformations in materials science.

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Area of Science:

  • Solid-state chemistry
  • Crystallography
  • Materials science

Background:

  • Polymorphism involves different crystal structures of the same elemental composition.
  • Solvatomorphism includes solvent molecules within crystal structures.
  • Understanding these phenomena is crucial for material properties and applications.

Purpose of the Study:

  • To provide a comprehensive overview of polymorphism and solvatomorphism research published in 2005.
  • To consolidate findings from major scientific journals and patents.
  • To highlight advancements in the study of crystal structure variations.

Main Methods:

  • Literature review of papers and patents published in 2005.
  • Categorization of research into general interest, computational, preparative, characterization, and phase transformation studies.
  • Analysis of US patents related to polymorphic and solvatomorphic systems.

Main Results:

  • Extensive coverage of computational and theoretical studies.
  • Detailed examination of preparative and isolation methods.
  • Characterization and property analysis of various polymorphic and solvatomorphic systems.

Conclusions:

  • The year 2005 saw significant research in polymorphism and solvatomorphism.
  • Advancements were made in understanding phase transformations and secondary processing effects.
  • Patents indicate continued industrial interest and application of these crystal forms.

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