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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
The Skin Microbiota01:27

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...
Infection01:20

Infection

When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...

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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Skin and soft tissue infections.

Fred A Lopez1, Serge Lartchenko

  • 1Section of Infectious Diseases, Department of Internal Medicine, Louisiana State University Health Sciences Center, Box E7-17, 2020 Gravier Street, New Orleans, LA 70112, USA. alopez1@lsuhsc.edu

Infectious Disease Clinics of North America
|November 23, 2006
PubMed
Summary

This article reviews primary skin infections (pyodermas) caused by bacteria like Streptococcus pyogenes and Staphylococcus aureus. It covers various types, from impetigo to necrotizing fasciitis, and predisposing host factors.

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Area of Science:

  • Dermatology and Infectious Diseases
  • Microbiology of Skin Pathogens

Background:

  • Primary skin infections, or pyodermas, arise from breaches in the epidermis.
  • Common culprits include skin colonizers like Streptococcus pyogenes and Staphylococcus aureus.
  • Host factors such as immunosuppression and neuropathy increase susceptibility.

Purpose of the Study:

  • To provide a comprehensive overview of common skin and soft tissue infections.
  • To discuss the pathogenesis, clinical presentations, and range of severity.
  • To highlight key diagnostic and management considerations for various pyodermas.

Main Methods:

  • Review of existing literature on skin and soft tissue infections.
  • Categorization of infections based on clinical syndromes and affected structures.
  • Discussion of causative organisms and predisposing host factors.

Main Results:

  • Skin infections present with characteristic syndromes, often defined by anatomical location.
  • Infections range from superficial (e.g., impetigo) to deep-seated (e.g., necrotizing fasciitis).
  • Specific conditions discussed include folliculitis, erysipelas, cellulitis, and pyomyositis.

Conclusions:

  • Understanding the spectrum of skin infections is crucial for timely diagnosis and treatment.
  • Prompt recognition of aggressive infections like necrotizing fasciitis is vital.
  • Management strategies should consider the specific pathogen and host factors involved.