Multiple lung adenocarcinomas and AAH treated by surgical resection

Atypical adenomatous hyperplasia (AAH) is often found in the lungs of patients with multiple primary lung adenocarcinoma; however, treatment for such patients has not been clearly defined. This report presents a case of multiple primary lung adenocarcinoma with multiple AAH treated by surgery. A 55-year-old man underwent two operations in 3 years and 8 months. Thirteen tumorous lesions were resected; 10 lesions were diagnosed as primary lung adenocarcinoma and the others as AAH. Two years and 6 months after the second operation, radiographic examination showed no evidence of tumor recurrence. The clinical course indicates that surgery can be a treatment strategy for synchronous or metachronous lung carcinoma with AAH.