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Using Eggs from Schistosoma mansoni as an In vivo Model of Helminth-induced Lung Inflammation
Published on: June 5, 2012
[Lymphoma in patients harboring hepatosplenic mansonic schistosomiasis]
Alvaro Antônio Bandeira Ferraz1, Vladimir Curvêlo Tavares de Sá, Edmundo Pessoa de Almeida Lopes
1Departamento de Cirurgia, Universidade Federal de Pernambuco, Recife, PE. aabf@truenet.com.br
Background:
Correlation between infectious agents and linfoproliferative diseases are more stablished, over all virus and bacteria, through the activation of linfocytes.
Aim:
To describe six new cases, of a series of 254 patients (2,36%) with mansonic schistosomiasis, in the hepatosplenic form.
Methods:
Six patients will be described, amongst the 254 carriers of mansonic schistosomiasis, in the hepatosplenic form, followed in the last 13 years.
Results:
All the six cases had occurred in women. The histopathologic examinations had evidenced two cases of marginal splenic zone lymphomas, one of great cells with immunoblasts lymphomas, one diffuse lymphomas, a great cells malignant lymphomas, a great not clivads cells, and another case of Hodgkin. Half of the six evolved for the death 4-15 months after the diagnosis. The others three persist in accompaniment in the Oncology Division of the Clinics Hospital.
Conclusion:
The incidence of lymphomas in the 254 mansonic schistosomiasis patients followed in our clinic was of 2,36%. At last, this article intends to call the attention, for the occurrence of lymphomas, in the spleen of patients with mansonic schistosomiasis, in the hepatosplenic form.
Insights
This study highlights a 2.36% incidence of lymphomas in patients with hepatosplenic schistosomiasis mansoni. These findings underscore the critical link between schistosomiasis mansoni infection and lymphoid malignancies.
Area of Science:
- Medical Research
- Oncology
- Infectious Diseases
Background:
- Infectious agents, particularly viruses and bacteria, are increasingly linked to lymphoproliferative diseases via lymphocyte activation.
- Schistosomiasis mansoni is a parasitic infection with a known hepatosplenic form.
Observation:
- Six new cases of lymphoma were identified in 254 patients (2.36%) with hepatosplenic schistosomiasis mansoni.
- All identified cases occurred in female patients.
- Histopathological examination revealed various types of lymphomas, including marginal zone lymphomas, diffuse lymphomas, and Hodgkin lymphoma.
Findings:
- Half of the patients diagnosed with lymphoma and schistosomiasis mansoni died within 4-15 months post-diagnosis.
- The remaining three patients continue to receive care in the Oncology Division.
- The study establishes a 2.36% incidence of lymphomas among the observed schistosomiasis mansoni cohort.
Implications:
- This research emphasizes the importance of considering lymphoma in patients diagnosed with hepatosplenic schistosomiasis mansoni.
- Increased awareness and diagnostic vigilance for lymphomas in this patient population are warranted.
- Further research into the mechanisms underlying the association between schistosomiasis mansoni and lymphoma development is crucial.
