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Fast chemical shift mapping with multiecho balanced SSFP.

Jochen Leupold1, Oliver Wieben, Sven Månsson

  • 1Department of Diagnostic Radiology, Medical Physics, University Hospital Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany. jochen.leupold@uniklinik-freiburg.de

Magma (New York, N.Y.)
|November 23, 2006
PubMed
Summary
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This study introduces a novel spectroscopic imaging method combining balanced steady-state free precession (bSSFP) with multiecho acquisition. This technique achieves high spatial and temporal resolution for rapid in vivo imaging and metabolite mapping.

Area of Science:

  • Magnetic Resonance Imaging
  • Spectroscopy
  • Medical Imaging

Background:

  • Balanced steady-state free precession (bSSFP) is a fast imaging technique.
  • Traditional bSSFP has limitations in spectral resolution due to short repetition times.
  • Achieving high spatial and spectral resolution simultaneously in short acquisition times is challenging.

Purpose of the Study:

  • To develop a spectroscopic imaging method with high spatial resolution and moderate spectral resolution.
  • To achieve very short total data acquisition times for spectroscopic imaging.
  • To enable rapid in vivo metabolite mapping.

Main Methods:

  • Combining balanced steady-state free precession (bSSFP) with a multiecho readout gradient.
  • Employing frequency-sensitive reconstruction techniques, such as Fourier reconstruction or matrix inversion.

Related Experiment Videos

  • Utilizing methods known from echo-planar spectroscopic imaging (EPSI).

    • Main Results:

    • Generated 2D spectroscopic images with high spatial resolution in 1-2 seconds.
    • Achieved water/fat separation in vivo.
    • Acquired fast 31P spectroscopic images from phantoms in 195 ms.

    Conclusions:

    • Frequency-sensitive reconstruction of multiecho bSSFP data yields high spatial and temporal resolution spectroscopic images.
    • Moderate spectral resolution (around 100 Hz) is achievable.
    • The method supports separation of multiple resonances for hetero-nuclear metabolite mapping (e.g., 13C, 31P).