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Small-volume hypertonic saline dextran resuscitation from canine endotoxin shock
1Department of Surgery, University of Texas Southwestern Medical Center, Dallas 75235-9031.
Annals of Surgery
|July 1, 1991
Summary
Hypertonic saline dextran (HSD) effectively resuscitated endotoxin shock in dogs by improving hemodynamics and regional blood flow. HSD required less fluid resuscitation and resulted in lower fluid gain compared to lactated Ringer's alone.
Area of Science:
- Veterinary Medicine
- Critical Care
- Pharmacology
Background:
- Endotoxin shock leads to severe cardiovascular dysfunction and acid-base imbalances.
- Effective resuscitation strategies are crucial for managing endotoxin shock.
Purpose of the Study:
- To evaluate the efficacy of 7.5% hypertonic saline dextran (HSD) in resuscitating endotoxin shock in a canine model.
- To compare hemodynamic and regional blood flow responses to HSD versus lactated Ringer's (LR) alone.
Main Methods:
- Endotoxin shock was induced in adult dogs.
- Dogs were resuscitated with either HSD followed by LR, or LR alone.
- Hemodynamic parameters (MABP, CO) and regional blood flow were measured.
Main Results:
- HSD resuscitation improved cardiac contraction and relaxation indices more than LR alone.
- The HSD group required significantly less LR volume and had a lower net fluid gain.
- Both resuscitation regimens corrected acid-base disturbances and improved regional perfusion similarly.
Conclusions:
- Hypertonic saline dextran is an effective resuscitation fluid for endotoxin shock in this canine model.
- HSD resuscitation leads to reduced fluid administration and lower fluid accumulation.
- HSD demonstrates superior enhancement of cardiac function during endotoxin shock resuscitation.