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Single nucleotide polymorphisms of tumor necrosis factor-alpha and the susceptibility to bronchopulmonary dysplasia

Sonya S Strassberg1, Ioana A Cristea, Dajun Qian

  • 1Department of Pediatrics, Division of Neonatology, New York Medical College, Maria Fareri Children's Hospital of Westchester Medical Center, Valhalla, NY 10595, USA. strassbergs@wcmc.com

Pediatric Pulmonology
|November 24, 2006
PubMed

Insights

This study investigated if tumor necrosis factor-alpha (TNFalpha) gene variations increase the risk of bronchopulmonary dysplasia (BPD) in preterm infants. No significant association was found between TNFalpha single nucleotide polymorphisms (SNPs) and BPD severity.

Area of Science:

  • Neonatology
  • Genetics
  • Pulmonology

Background:

  • Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in infants.
  • A "New" BPD phenotype involves arrested lung development, potentially influenced by pro-inflammatory genes like tumor necrosis factor-alpha (TNFalpha).

Purpose of the Study:

  • To determine if single nucleotide polymorphisms (SNPs) in the TNFalpha gene are associated with an increased risk or severity of BPD in preterm infants.

Main Methods:

  • Analyzed DNA from 105 preterm infants (<1 kg birthweight) for five TNFalpha SNPs (-1,031, -863, -857, -308, -238).
  • Reconstructed haplotypes and estimated frequencies using PHASE software.
  • Stratified infants for BPD severity based on oxygen requirements.

Main Results:

  • No significant association was found between BPD severity and common 5-marker TNFalpha haplotypes.
  • No significant association was observed for three-SNP haplotypes (-1,031, -863, -857) or two-SNP haplotypes (-308, -238).
  • The five investigated TNFalpha SNPs showed no association with BPD severity.

Conclusions:

  • The study found no evidence that the investigated TNFalpha gene SNPs or their haplotypes are associated with the severity of bronchopulmonary dysplasia in preterm infants.

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