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Hookworm infestation as a risk factor for Mooren's ulcer in South India

Joseph R Zelefsky1, Muthaiah Srinivasan, Arunava Kundu

  • 1New York University School of Medicine, New York, New York, USA.

Ophthalmology
|November 25, 2006
PubMed
Abstract

Insights

Intestinal hookworm infestation is linked to Mooren's ulcer in South India. This association appears stronger in older males, suggesting a potential etiological factor for this serious eye condition.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Parasitology

Background:

  • Mooren's ulcer is a rare, destructive peripheral ulcerative keratitis.
  • Intestinal parasitic infections are prevalent in many tropical and subtropical regions.

Purpose of the Study:

  • To investigate the association between Mooren's ulcer and intestinal hookworm infestation in South India.
  • To explore potential demographic factors influencing this association.

Main Methods:

  • A prospective observational case-control study was conducted.
  • Fifteen Mooren's ulcer patients and 30 matched controls provided stool samples.
  • Stool samples were analyzed for hookworm infestation.

Main Results:

  • A statistically significant correlation was found between hookworm infestation and Mooren's ulcer (P = 0.009).
  • The correlation was stronger in males (P<0.0001) and in individuals over 50 years old (P = 0.017).
  • No significant difference in hookworm prevalence was observed in females or individuals 50 years or younger.

Conclusions:

  • Intestinal hookworm infestation is associated with Mooren's ulcer development in South India.
  • The association may be more pronounced in older males, warranting further investigation.

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