Related Experiment Video
Updated: Jul 18, 2026

Split Point Analysis and Uncertainty Quantification of Thermal-Optical Organic/Elemental Carbon Measurements
Published on: September 7, 2019
Analyzing the "correct" endpoint
Pamela J Atherton1, Paul J Novotny, Angelina D Tan
1Department of Health Science Research, Mayo Clinic, Rochester, Minnesota, USA.
Abstract:
The choice of QOL endpoints for a study should be based on which score will most likely change if the treatment is favorable. How the QOL change is calculated should be based on the expected amount of missing data, how many time points data will be collected, and whether extreme outliers in the scores impact results. The study should have sufficient power to detect a meaningful difference between arms (typically 10 points on a 0-100 point scale) in the chosen QOL endpoint. At the conclusion of a study, several secondary endpoints can be analyzed which can provide additional information and confirm primary endpoint results.
Related Concept Videos
Effects of EDTA on End-Point Detection Methods
In the visual method, metal-ion indicators (metallochromic dyes), which have distinct colors in their free and complex forms, are added to the mixture to signal the titration's end point. They form stable complexes with metal ions, but these complexes are weaker than the corresponding metal–EDTA complexes. As a result, EDTA...
Precipitation Titration: Endpoint Detection Methods
In the Volhard method, a standard excess of AgNO3 is first added to the...
End Point Prediction: Gran Plot
For potentiometric titration, the Gran plot is created by plotting the...
Titration of Polyprotic Base with a Strong Acid
Titration of a Weak Acid with a Weak Base
As a result, there is no simple...
Controlled-Current Coulometry: Overview

