Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

3D Bioprinted Tumor Constructs for Photothermal Therapy: Emerging Opportunities in Microgravity Research.

Methods in molecular biology (Clifton, N.J.)·2026

Same author

Circulating extracellular vesicles from early-stage lung cancer patients trigger endothelial activation to drive pre-metastatic niche formation through synergistic miR-29a and C4A signaling.

Journal of experimental & clinical cancer research : CR·2026

Same author

Modulation of L-Type Calcium Currents by Resveratrol-Induced Myogenesis in C2C12 Cells.

Cells·2026

Same author

Notch1 deletion reduces arrhythmogenic remodeling after myocardial infarction.

Heart rhythm·2026

Same author

Polyethylene nano- and microplastics trigger metabolic stress responses in human vaginal epithelial cells.

Cell death discovery·2026

Same author

Benefits of sacubitril/valsartan alone and in combination with dapagliflozin in a preclinical female model of cardiometabolic and age-related cardiac dysfunction.

Cardiovascular diabetology·2026

Search research articles

Related Experiment Video

Updated: Jul 18, 2026

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model

Published on: September 3, 2020

Concise review: stem cells, myocardial regeneration, and methodological artifacts.

Piero Anversa¹, Annarosa Leri, Marcello Rota

¹Cardiovascular Research Institute, Vosburgh Pavilion, New York Medical College, Valhalla, NY 10595, USA. piero_anversa@nymc.edu.

Stem Cells (Dayton, Ohio)

|November 25, 2006

Summary

This review explores progenitor cells in heart repair. It challenges the idea that findings are artifacts, suggesting the heart can regenerate cardiomyocytes from resident stem cells or via hematopoietic stem cell administration.

More Related Videos

Intramyocardial Cell Delivery: Observations in Murine Hearts

Intramyocardial Cell Delivery: Observations in Murine Hearts

Published on: January 24, 2014

Coronary Artery Ligation and Intramyocardial Injection in a Murine Model of Infarction

Coronary Artery Ligation and Intramyocardial Injection in a Murine Model of Infarction

Published on: June 7, 2011

Related Experiment Videos

Last Updated: Jul 18, 2026

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model

Published on: September 3, 2020

Intramyocardial Cell Delivery: Observations in Murine Hearts

Intramyocardial Cell Delivery: Observations in Murine Hearts

Published on: January 24, 2014

Coronary Artery Ligation and Intramyocardial Injection in a Murine Model of Infarction

Coronary Artery Ligation and Intramyocardial Injection in a Murine Model of Infarction

Published on: June 7, 2011

Area of Science:

Cardiovascular Biology
Regenerative Medicine
Stem Cell Research

Background:

The heart's capacity for self-repair after injury is debated.
The role of endogenous and exogenous progenitor cells in cardiac homeostasis is controversial.
Previous findings on cardiac regeneration have been attributed to technical artifacts.

Purpose of the Study:

To review the controversy surrounding progenitor cells in cardiac regeneration.
To challenge the static view of cardiac growth.
To present evidence supporting the heart's inherent regenerative potential.

Main Methods:

Literature review of studies on cardiac progenitor cells.
Analysis of findings related to myocardial regeneration.
Discussion of arguments for and against stem cell-mediated cardiac repair.

Main Results:

The review challenges the interpretation of findings as mere technical artifacts.
Evidence suggests the mammalian heart possesses regenerative capabilities.
Both resident primitive cells and administered hematopoietic stem cells are implicated in repair.

Conclusions:

The heart has an inherent ability to replace cardiomyocytes.
Activation of resident stem cells contributes to cardiac repair.
Hematopoietic stem cells may be administered for myocardial regeneration.