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A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
Published on: April 2, 2012
Herpes zoster laryngitis: case report and serological profile
Jean-Baptiste Watelet1, Anne-Sophie Evrard, Georges Lawson
1Department of Otorhinolaryngology and Head & Neck Surgery, Ghent University Hospital, Ghent, Belgium. jeanbaptiste.watelet@ugent.be
Summary
Varicella zoster virus (VZV) reactivation in the larynx is rare in immunocompetent individuals. This case highlights laryngeal zoster without vocal cord paralysis, detailing the sensory nerve distribution and serological VZV antibody response.
Area of Science:
- Otolaryngology
- Neurology
- Infectious Diseases
Background:
- Varicella zoster virus (VZV) reactivation, commonly known as shingles, typically affects dermatomes but can occur in cranial nerves.
- Laryngeal zoster, a rare manifestation, is often associated with vocal cord paralysis due to motor nerve involvement.
- This report focuses on a unique case of laryngeal zoster in an immunocompetent patient without motor deficits.
Observation:
- The patient presented with vesicles localized to the sensory distribution of the left superior laryngeal nerve.
- No vocal cord paralysis or other motor impairments were observed.
- The distribution of mucosal eruptions was mapped to specific neuroanatomical structures.
Findings:
- Serological testing revealed a distinct pattern of VZV IgM and IgG antibody response.
- Antibody levels peaked approximately one month after symptom onset.
- Significant modifications in VZV IgM and IgG profiles persisted for up to four months post-initial symptoms.
Implications:
- This case expands the clinical spectrum of laryngeal VZV reactivation, emphasizing presentations without motor sequelae.
- Understanding the neuroanatomical distribution of eruptions aids in diagnosis and management.
- The prolonged serological response highlights the importance of monitoring VZV antibody titers in specific laryngeal presentations.
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