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Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
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Published on: August 30, 2014

Sublingual vaccines based on wild-type recombinant allergens

L Van Overtvelt1, A Razafindratsita, N St-Lu

  • 1Stallergènes SA - 6, rue Alexis de Tocqueville - 92160 Antony, France.

European Annals of Allergy and Clinical Immunology
|November 28, 2006
PubMed

Sublingual immunotherapy (SLIT) represents a non invasive alternative to subcutaneous immunotherapy in order to treat type I allergies. Vaccines based on recombinant allergens expressed in a native (i.e. wild-type) configuration, formulated with ad hoc adjuvants designed to target Langerhans cells in the sublingual mucosa should allow to induce allergen-specific regulatory T cells. In this context, we have developed animal and human preclinical models to test the capacity of candidate vaccines to modulate selectively allergen-specific T helper lymphocyte polarization following sublingual vaccination.

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