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Updated: Jul 18, 2026

Bioassays for Monitoring Insecticide Resistance
06:30

Bioassays for Monitoring Insecticide Resistance

Published on: December 30, 2010

Which came first: insecticides or resistance?

Richard H Ffrench-Constant1

  • 1Centre for Ecology and Conservation, School of Biosciences, University of Exeter, Cornwall Campus, Tremough, Cornwall TR10 9EZ, UK. r.ffrench-Constant@exeter.ac.uk

Trends in Genetics : TIG
|November 28, 2006
PubMed
Summary

Insecticide resistance mutations in Australian sheep blowflies were detected before Malathion was introduced. This suggests pre-existing resistance alleles may not incur a fitness cost, impacting our understanding of new compound resistance.

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Area of Science:

  • * Evolutionary biology
  • * Insecticide resistance genetics
  • * Pest management

Background:

  • * Insecticide resistance is a significant challenge in pest management.
  • * The evolutionary origin of resistance mutations (pre- or post-insecticide introduction) has been difficult to ascertain.
  • * Understanding the fitness costs associated with resistance alleles is crucial for effective control strategies.

Purpose of the Study:

  • * To investigate the temporal origin of insecticide resistance mutations.
  • * To determine if resistance alleles to Malathion existed in Australian sheep blowfly populations prior to the insecticide's widespread use.
  • * To assess the potential fitness implications of pre-existing resistance alleles.

Main Methods:

  • * Analysis of genetic material from historical pinned specimens of Australian sheep blowflies.

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Last Updated: Jul 18, 2026

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Published on: December 30, 2010

Study on the Metabolism of Six Systemic Insecticides in a Newly Established Cell Suspension Culture Derived from Tea (Camellia Sinensis L.) Leaves
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  • * Detection of specific mutations conferring resistance to Malathion in pre-introduction samples.
  • * Comparative genetic analysis to infer the timing of mutation emergence.

    • Main Results:

    • * Malathion resistance mutations were identified in Australian sheep blowfly specimens collected before the introduction of Malathion.
    • * This provides direct evidence for the pre-existence of these resistance alleles in the population.
    • * The findings suggest that pre-existing resistance alleles may not impose a significant fitness penalty.

    Conclusions:

    • * Insecticide resistance can pre-date the introduction of the selective agent.
    • * Pre-existing resistance alleles may be maintained in populations without a substantial fitness cost.
    • * This has critical implications for predicting the evolution of resistance to new insecticides and developing sustainable pest management strategies.