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Published on: July 4, 2017
Thermo- and pH-responsive polymers in drug delivery
1Centre for Polymer Therapeutics, Welsh School of Pharmacy, Cardiff University and Cardiff Institute of Tissue Engineering and Repair (CITER), Redwood Building, King Edward VII Avenue, Cardiff, CF10 3XF, Wales, UK. schmaljohannd@cf.ac.uk
Stimuli-responsive polymers offer
Area of Science:
- Biomaterials science
- Polymer chemistry
- Drug delivery systems
Background:
- Stimuli-responsive polymers exhibit significant property changes with environmental variations like pH or temperature.
- These polymers are key to developing 'smart' drug delivery systems that mimic biological responses.
- Biomedical applications favor stimuli like pH due to physiological variations across organs and tissues.
Purpose of the Study:
- To review pH-responsive and thermo-responsive polymers for drug delivery.
- To explore double-responsive systems.
- To discuss the underlying physico-chemical behavior and applications.
Main Methods:
- Literature review of pH-responsive and thermo-responsive polymers.
- Analysis of physico-chemical principles of phase transitions.
- Selection and description of relevant application examples.
Main Results:
- pH and temperature are suitable stimuli for 'smart' drug delivery systems.
- The paper details the behavior of pH-responsive polymers extensively.
- Thermo-responsive and double-responsive systems are also discussed.
Conclusions:
- Stimuli-responsive polymers are crucial for advanced drug delivery.
- pH-responsive systems are particularly promising for targeted delivery.
- Understanding polymer behavior is essential for effective application design.
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