Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Emerging concepts in molecular MRI.

David E Sosnovik1, Ralph Weissleder

  • 1Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. sosnovik@nmr.mgh.harvard.edu

Current Opinion in Biotechnology
|November 28, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Carvedilol Exerts Cardioprotective Effects Against Doxorubicin Toxicity via Autophagy Modulation and Energetics Restoration.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

Diffusion Tensor MRI of the Heart: The Toolbox Continues to Grow.

Circulation. Cardiovascular imaging·2026
Same author

<i>Ex vivo</i> phosphorus-31 solid state magnetic resonance spectroscopy identifies compositional differences between bone mineral and calcified vascular tissues.

Frontiers in cardiovascular medicine·2025
Same author

<i>Ex Vivo</i> Phosphorus-31 Solid State Magnetic Resonance Spectroscopy Identifies Compositional Differences Between Bone Mineral and Calcified Vascular Tissues.

medRxiv : the preprint server for health sciences·2025
Same author

Decoration of Autophagy Detecting Nanoparticle with an Anionic Fluorochrome Enhances Multispectral Characterization of Autophagosome Location and Flux.

Small (Weinheim an der Bergstrasse, Germany)·2024
Same author

Collagen Pyridinoline Cross-Links Are Absent in Reversible Myocardial Fibrosis.

Circulation research·2024
Same journal

Upcycling food processing byproducts via advanced yeast fermentation.

Current opinion in biotechnology·2026
Same journal

Microbial C1 assimilation pathways for chemical synthesis: from native metabolism to synthetic design.

Current opinion in biotechnology·2026
Same journal

Medicinal plants fermentation: current knowledge and perspectives.

Current opinion in biotechnology·2026
Same journal

Fermented foods: lessons learned from metagenomics.

Current opinion in biotechnology·2026
Same journal

Microfluidic platforms for the transient transfection of mammalian cells: recent developments and challenges.

Current opinion in biotechnology·2026
Same journal

Harvesting insights from recent advances in yeast genomics for predictable and precision wine fermentation.

Current opinion in biotechnology·2026
See all related articles

Molecular magnetic resonance imaging (MRI) advances enable cellular-level imaging using targeted contrast agents and novel nanoparticles. These innovations promise enhanced diagnostic specificity and potential for clinical translation.

Area of Science:

  • Biomedical Imaging
  • Nanotechnology
  • Molecular Biology

Background:

  • Molecular magnetic resonance imaging (MRI) is advancing rapidly, enabling visualization of cellular and subcellular events.
  • Targeted contrast agents and novel nanoparticles are expanding the capabilities of in vivo imaging.

Purpose of the Study:

  • To review recent advances in molecular MRI.
  • To highlight the development of novel contrast agents, biosensors, and imaging techniques.
  • To discuss the potential for clinical translation of these technologies.

Main Methods:

  • Development of targeted MR contrast agents for specific biomarkers.
  • High-throughput screening of nanoparticle libraries for novel contrast agents.
  • Design of magnetic nanoparticles as dynamic event imaging 'switches' (biosensors).

Related Experiment Videos

  • Application of specialized MR probes for enzyme activity imaging.
  • Utilizing chemical exchange and off-resonance techniques for enhanced imaging.

    • Main Results:

    • Targeted agents allow imaging of sparsely expressed biological targets in vivo.
    • Nanoparticles offer enhanced diagnostic specificity and range.
    • Magnetic nanoparticle 'switches' function as biosensors for dynamic events.
    • Specialized probes enable in vivo enzyme activity imaging.
    • Advanced techniques add multispectral imaging capabilities to molecular MRI.

    Conclusions:

    • Molecular MRI has seen significant advances, including targeted agents and novel nanoparticles.
    • New biosensors and imaging techniques expand the scope of molecular MRI.
    • These developments hold substantial promise for future clinical applications.